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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-8-28
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pubmed:abstractText |
Colorectal cancer is associated with a "field change" of increased proliferation throughout the colonic and rectal mucosa. Both proliferation and apoptosis are disrupted during carcinogenesis. Whether altered apoptosis contributes to this field change of microscopic abnormality is, however, unclear. Bcl-xL is an anti-apoptotic protein that inhibits apoptosis by preventing release of cytochrome c, a recognised pathway to cell death.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9746
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
942-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16679352-Adenocarcinoma,
pubmed-meshheading:16679352-Aged,
pubmed-meshheading:16679352-Aged, 80 and over,
pubmed-meshheading:16679352-Apoptosis,
pubmed-meshheading:16679352-Cell Proliferation,
pubmed-meshheading:16679352-Colorectal Neoplasms,
pubmed-meshheading:16679352-Female,
pubmed-meshheading:16679352-Humans,
pubmed-meshheading:16679352-Immunoenzyme Techniques,
pubmed-meshheading:16679352-Intestinal Mucosa,
pubmed-meshheading:16679352-Male,
pubmed-meshheading:16679352-Middle Aged,
pubmed-meshheading:16679352-Neoplasm Proteins,
pubmed-meshheading:16679352-bcl-X Protein
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pubmed:year |
2006
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pubmed:articleTitle |
A "field change" of inhibited apoptosis occurs in colorectal mucosa adjacent to colorectal adenocarcinoma.
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pubmed:affiliation |
Department of Surgery, Chelsea & Westminster Hospital, London, UK. sara.badvie@doctors.org.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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