| pubmed-article:16679034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16679034 | lifeskim:mentions | umls-concept:C0007226 | lld:lifeskim |
| pubmed-article:16679034 | lifeskim:mentions | umls-concept:C0026447 | lld:lifeskim |
| pubmed-article:16679034 | lifeskim:mentions | umls-concept:C0039451 | lld:lifeskim |
| pubmed-article:16679034 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:16679034 | lifeskim:mentions | umls-concept:C0429028 | lld:lifeskim |
| pubmed-article:16679034 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:16679034 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16679034 | pubmed:dateCreated | 2006-9-4 | lld:pubmed |
| pubmed-article:16679034 | pubmed:abstractText | Preclinical evaluation of delayed ventricular repolarization manifests electrocardiographically as QT interval prolongation and is routinely used as an indicator of potential risk for pro-arrhythmia (potential to cause Torsades de Pointes) of novel human pharmaceuticals. In accordance with ICH S7A and S7B guidelines we evaluated the sensitivity and validity of the monkey telemetry model as a preclinical predictor of QT interval prolongation in humans. | lld:pubmed |
| pubmed-article:16679034 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16679034 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16679034 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16679034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16679034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16679034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16679034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16679034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16679034 | pubmed:issn | 1056-8719 | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:WilliamsM AMA | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:O'SullivanSS | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:KellerW JWJ | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:WareP EPE | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:HoeC MCM | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:BriscoeR JRJ | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:MixsonLL | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:ChavesA AAA | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:FitzgeraldL... | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:McPhersonH... | lld:pubmed |
| pubmed-article:16679034 | pubmed:author | pubmed-author:GoykhmanDD | lld:pubmed |
| pubmed-article:16679034 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16679034 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:16679034 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16679034 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16679034 | pubmed:pagination | 150-8 | lld:pubmed |
| pubmed-article:16679034 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:16679034 | pubmed:articleTitle | Cardiovascular monkey telemetry: sensitivity to detect QT interval prolongation. | lld:pubmed |
| pubmed-article:16679034 | pubmed:affiliation | Safety Assessment, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, United States. | lld:pubmed |
| pubmed-article:16679034 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16679034 | lld:pubmed |
