|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-9-4
|
|
pubmed:abstractText |
Preclinical evaluation of delayed ventricular repolarization manifests electrocardiographically as QT interval prolongation and is routinely used as an indicator of potential risk for pro-arrhythmia (potential to cause Torsades de Pointes) of novel human pharmaceuticals. In accordance with ICH S7A and S7B guidelines we evaluated the sensitivity and validity of the monkey telemetry model as a preclinical predictor of QT interval prolongation in humans.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1056-8719
|
|
pubmed:author |
pubmed-author:BriscoeR JRJ,
pubmed-author:ChavesA AAA,
pubmed-author:FitzgeraldL ELE,
pubmed-author:GoykhmanDD,
pubmed-author:HoeC MCM,
pubmed-author:KellerW JWJ,
pubmed-author:McPhersonH EHE,
pubmed-author:MixsonLL,
pubmed-author:O'SullivanSS,
pubmed-author:WareP EPE,
pubmed-author:WilliamsM AMA
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
150-8
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16679034-Algorithms,
pubmed-meshheading:16679034-Animals,
pubmed-meshheading:16679034-Anti-Infective Agents,
pubmed-meshheading:16679034-Aza Compounds,
pubmed-meshheading:16679034-Blood Pressure,
pubmed-meshheading:16679034-Dose-Response Relationship, Drug,
pubmed-meshheading:16679034-Electrocardiography,
pubmed-meshheading:16679034-Electrodes, Implanted,
pubmed-meshheading:16679034-Excipients,
pubmed-meshheading:16679034-Heart Rate,
pubmed-meshheading:16679034-Hemodynamics,
pubmed-meshheading:16679034-Long QT Syndrome,
pubmed-meshheading:16679034-Macaca mulatta,
pubmed-meshheading:16679034-Male,
pubmed-meshheading:16679034-Methylcellulose,
pubmed-meshheading:16679034-Quinolines,
pubmed-meshheading:16679034-Telemetry
|
|
pubmed:articleTitle |
Cardiovascular monkey telemetry: sensitivity to detect QT interval prolongation.
|
|
pubmed:affiliation |
Safety Assessment, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, United States.
|
|
pubmed:publicationType |
Journal Article
|
