Linked Life Data

16679008

Source:http://linkedlifedata.com/resource/pubmed/id/16679008

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-6-5
pubmed:abstractText
The relationship between electric charge at a material surface and protein adsorption is essential to understand the mechanism of biological integration of materials with tissues. This study investigated the influence of titanium thin films' surface chemistry and surface electric charge (zeta-potential) properties on protein adsorption and cell proliferation. Titanium thin films were surface functionalized with different functional end groups, such as -CH=CH2, -NH2 and -COOH groups in order to produce surfaces with a variety of electric charge properties. The chemical compositions, electric charges and wettability were investigated by using X-ray photoelectron spectroscopy (XPS), zeta-potential measurements and water contact angle measurements, respectively. XPS revealed the surface functionalization of titanium films with -CH=CH2, -NH2, and -COOH groups, which were converted from -CH=CH2 groups. Ti-COOH samples showed the lowest water contact angles and zeta-potential compared to all other samples investigated in this study. NH2-terminated titanium films displayed intermediate contact angles of 70.3+/-2.5 degrees . Fibrinogen adsorption on titanium films and surface functionalized titanium films were investigated in this study. Ti-COOH samples displayed a lower protein adsorption than all other groups, such as NH2-, -CH=CH2-terminated titanium thin films. A tendency that the lower zeta-potential of the samples, the lower the protein adsorption at their surfaces was observed. In vitro cell proliferation tests were also performed on the different surface functionalized titanium films. NH2-terminated titanium films displayed good cell proliferation and cell viability tendency. However, a lower cell proliferation on COOH-terminated titanium films was observed compared with NH2-terminated titanium films. This effect was attributed to the difference in protein adsorption of these samples.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0927-7765
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:dateRevised
2009-10-16
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Surface functionalized titanium thin films: zeta-potential, protein adsorption and cell proliferation.
pubmed:affiliation
Institute of Materials Science and Technology (IMT), Friedrich-Schiller-Universität Jena, Löbdergraben 32, D-07743 Jena, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't