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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-6-23
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pubmed:abstractText |
There is growing evidence indicating that oxidative stress is a key contributor to the pathogenesis and progression of Parkinson's disease. The brain, and particularly the basal ganglia, possesses a local rennin-angiotensin system. Angiotensin activates NAD(P)H-dependent oxidases, which are a major intracellular source of superoxide, and angiotensin converting enzyme inhibitors (ACEIs) have shown antioxidant properties. We treated mice with MPTP and the ACEI captopril to study the possible neuroprotective and antioxidant effects of the latter on the dopaminergic system. Pre-treatment with captopril induced a significant reduction in the MPTP-induced loss of dopaminergic neurons in the substantia nigra and a significant reduction in the loss of dopaminergic terminals in the striatum. Furthermore, captopril reduced the MPTP-induced increase in the levels of major oxidative stress indicators (i.e. lipid peroxidation and protein oxidation) in the ventral midbrain and the striatum. Captopril did not reduce striatal MPP(+) levels, MAO-B activity or dopamine transporter activity, which may reduce MPTP neurotoxicity. Our results suggest that angiotensin-converting enzyme inhibitors may be useful for treatment of Parkinson's disease, and that further investigation should focus on the neuroprotective capacity of these compounds.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(4-methoxyphenyl)pyridinium,
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-4-phenyl-1,2,3,6-tetrahydro...,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Antiparkinson Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Captopril,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridinium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0028-3908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16678218-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:16678218-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:16678218-Animals,
pubmed-meshheading:16678218-Antiparkinson Agents,
pubmed-meshheading:16678218-Captopril,
pubmed-meshheading:16678218-Dopamine,
pubmed-meshheading:16678218-Dopamine Agents,
pubmed-meshheading:16678218-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:16678218-Immunohistochemistry,
pubmed-meshheading:16678218-Lipid Peroxidation,
pubmed-meshheading:16678218-Male,
pubmed-meshheading:16678218-Mesencephalon,
pubmed-meshheading:16678218-Mice,
pubmed-meshheading:16678218-Mice, Inbred C57BL,
pubmed-meshheading:16678218-Mitochondria,
pubmed-meshheading:16678218-Monoamine Oxidase,
pubmed-meshheading:16678218-Neostriatum,
pubmed-meshheading:16678218-Nerve Degeneration,
pubmed-meshheading:16678218-Nerve Endings,
pubmed-meshheading:16678218-Nerve Tissue Proteins,
pubmed-meshheading:16678218-Neuroprotective Agents,
pubmed-meshheading:16678218-Oxidative Stress,
pubmed-meshheading:16678218-Parkinson Disease, Secondary,
pubmed-meshheading:16678218-Pyridinium Compounds,
pubmed-meshheading:16678218-Synaptosomes,
pubmed-meshheading:16678218-Tyrosine 3-Monooxygenase
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pubmed:year |
2006
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pubmed:articleTitle |
Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism.
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pubmed:affiliation |
Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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