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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-5-8
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pubmed:abstractText |
While the biological roles of canonical Wnt/beta-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of beta-catenin remains a major challenge. Here, we report an unexpected strategy for beta-catenin-dependent regulation of cell-lineage determination based on interactions between beta-catenin and a specific homeodomain factor, Prop1, rather than Lef/Tcfs. beta-catenin acts as a binary switch to simultaneously activate expression of the critical lineage-determining transcription factor, Pit1, and to repress the gene encoding the lineage-inhibiting transcription factor, Hesx1, acting via TLE/Reptin/HDAC1 corepressor complexes. The strategy of functionally distinct actions of a homeodomain factor in response to Wnt signaling is suggested to be prototypic of a widely used mechanism for generating diverse cell types from pluripotent precursor cells in response to common signaling pathways during organogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hdac1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hesx1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphoid Enhancer-Binding Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Pit1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Prophet of Pit-1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor Pit-1,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:GrosschedlRudolfR,
pubmed-author:KemlerRolfR,
pubmed-author:KronesAnnaA,
pubmed-author:LiXueX,
pubmed-author:OhgiKenneth AKA,
pubmed-author:OlsonLorin ELE,
pubmed-author:RoseDaveD,
pubmed-author:RosenfeldMichael GMG,
pubmed-author:ScafoglioClaudioC,
pubmed-author:TaketoMakoto MMM,
pubmed-author:TollkuhnJessicaJ,
pubmed-author:WuWeiW,
pubmed-author:ZhangJieJ
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-605
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16678101-Animals,
pubmed-meshheading:16678101-Cell Differentiation,
pubmed-meshheading:16678101-Cell Lineage,
pubmed-meshheading:16678101-HeLa Cells,
pubmed-meshheading:16678101-Histone Deacetylase 1,
pubmed-meshheading:16678101-Histone Deacetylases,
pubmed-meshheading:16678101-Homeodomain Proteins,
pubmed-meshheading:16678101-Humans,
pubmed-meshheading:16678101-Lymphoid Enhancer-Binding Factor 1,
pubmed-meshheading:16678101-Mice,
pubmed-meshheading:16678101-Mice, Knockout,
pubmed-meshheading:16678101-Mice, Transgenic,
pubmed-meshheading:16678101-Organogenesis,
pubmed-meshheading:16678101-Repressor Proteins,
pubmed-meshheading:16678101-Signal Transduction,
pubmed-meshheading:16678101-Transcription Factor Pit-1,
pubmed-meshheading:16678101-Transcriptional Activation,
pubmed-meshheading:16678101-Wnt Proteins,
pubmed-meshheading:16678101-beta Catenin
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pubmed:year |
2006
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pubmed:articleTitle |
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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