rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1992-6-26
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pubmed:abstractText |
A specific IgM solid-phase enzyme-linked immunoassay for the diagnosis of a recent infection by hepatitis C virus (HCV) was developed. The assay utilizes a structural antigen encoded by sequences at the 5' end of HCV (core region) and non-structural (NS) antigens encoded by the NS-3 (33c) and NS-4 (c100-3) regions of the HCV genome. Serial serum samples from several clinically diagnosed post-transfusion non-A, non-B hepatitis patients were analyzed for anti-HCV IgM. This antibody was frequently but transiently detected. Anti-HCV core IgM was more frequently detected than anti-c100-3 or anti-33c IgM. In individuals who resolved their HCV infection or progressed to chronicity, anti-HCV IgM was produced transiently at or near the onset of clinically diagnosed acute hepatitis.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/C100 protein, hepatitis C virus,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Nonstructural Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/nucleocapsid protein, Hepatitis C...
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pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0166-0934
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
35
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
343-52
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1667792-Acute Disease,
pubmed-meshheading:1667792-Antigens, Viral,
pubmed-meshheading:1667792-Chronic Disease,
pubmed-meshheading:1667792-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1667792-Hepacivirus,
pubmed-meshheading:1667792-Hepatitis Antibodies,
pubmed-meshheading:1667792-Hepatitis C,
pubmed-meshheading:1667792-Humans,
pubmed-meshheading:1667792-Immunoglobulin M,
pubmed-meshheading:1667792-Viral Core Proteins,
pubmed-meshheading:1667792-Viral Nonstructural Proteins,
pubmed-meshheading:1667792-Viral Proteins
|
pubmed:year |
1991
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pubmed:articleTitle |
IgM-antibody response to hepatitis C virus antigens in acute and chronic post-transfusion non-A, non-B hepatitis.
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pubmed:affiliation |
Experimental Biology Research, Abbott Laboratories, North Chicago, IL.
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pubmed:publicationType |
Journal Article
|