Linked Life Data

16677861

Source:http://linkedlifedata.com/resource/pubmed/id/16677861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2006-6-28
pubmed:abstractText
We generated several attenuated recombinant influenza A vectors expressing the Mycobacterium tuberculosis early secretory antigenic target (ESAT-6) protein. The ESAT-6 protein was recently identified as one of the most promising protective antigens for cell-mediated immunity. The obtained vectors appeared to be capable of inducing ESAT-6 specific Th1 immune response in mice after intranasal immunization. We found that double immunization with two influenza vectors of different subtypes provided a significant level of protection in mice, when applied as prophylactic vaccine, as well as substantial therapeutic effect in mice with pre-established tuberculosis infection. Moreover, we found a strong synergistic effect when vaccination with Flu/ESAT-6 vectors was combined with isoniazid treatment, resulting in a dramatic reduction of bacterial load in the lungs of infected mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1472-9792
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
236-46
pubmed:dateRevised
2009-4-22
pubmed:meshHeading
pubmed:articleTitle
Vaccine potential of influenza vectors expressing Mycobacterium tuberculosis ESAT-6 protein.
pubmed:affiliation
Influenza Research Institute, Russian Academy of Medical Sciences, St. Petersburg.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't