|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
2006-6-1
|
|
pubmed:abstractText |
The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H(3) receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H(3) receptors are reported.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:BeaversLisa SLS,
pubmed-author:CramerJeffrey WJW,
pubmed-author:DillJoelleJ,
pubmed-author:FinleyDon RDR,
pubmed-author:GadskiRobert ARA,
pubmed-author:HipskindPhilip APA,
pubmed-author:JesudasonCynthia DCD,
pubmed-author:LindsleyCraig WCW,
pubmed-author:OldhamSamuel WSW,
pubmed-author:PickardR ToddRT,
pubmed-author:SiedemChristopher SCS,
pubmed-author:SindelarDana KDK,
pubmed-author:SinghAjayA,
pubmed-author:StevensF CraigFC,
pubmed-author:WatsonBrian MBM
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3415-8
|
|
pubmed:dateRevised |
2010-4-12
|
|
pubmed:meshHeading |
pubmed-meshheading:16677814-Animals,
pubmed-meshheading:16677814-Azepines,
pubmed-meshheading:16677814-Drug Evaluation, Preclinical,
pubmed-meshheading:16677814-Humans,
pubmed-meshheading:16677814-Molecular Structure,
pubmed-meshheading:16677814-Rats,
pubmed-meshheading:16677814-Receptors, Histamine H3,
pubmed-meshheading:16677814-Structure-Activity Relationship,
pubmed-meshheading:16677814-Tetrahydroisoquinolines
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Synthesis and SAR of novel histamine H3 receptor antagonists.
|
|
pubmed:affiliation |
Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. jesudason_cynthia_d@lilly.com
|
|
pubmed:publicationType |
Journal Article
|
