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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-5-8
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pubmed:abstractText |
Severe injury to the liver, such as that induced by toxic doses of acetaminophen, triggers a cascade of events leading to hepatocyte death. It is hypothesized that activation of the receptor for advanced glycation end products (RAGE) might contribute to acetaminophen-induced liver toxicity by virtue of its ability to generate reactive oxygen species, at least in part via nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and thereby activate downstream signaling pathways leading to cellular injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0815-9319
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pubmed:author |
pubmed-author:DunHaoH,
pubmed-author:EkongUdemeU,
pubmed-author:EmondJean CJC,
pubmed-author:FeirtNikkiN,
pubmed-author:GuarreraJames VJV,
pubmed-author:GuoJianchengJ,
pubmed-author:IppaguntaNikaleshN,
pubmed-author:KAYL MLM,
pubmed-author:RamasamyRavichandranR,
pubmed-author:SchmidtAnn MarieAM,
pubmed-author:WeinbergAlanA,
pubmed-author:WinSS,
pubmed-author:ZengShanS
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
682-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16677153-Acetaminophen,
pubmed-meshheading:16677153-Animals,
pubmed-meshheading:16677153-Drug-Induced Liver Injury,
pubmed-meshheading:16677153-Glycosylation End Products, Advanced,
pubmed-meshheading:16677153-Inflammation Mediators,
pubmed-meshheading:16677153-Liver Diseases,
pubmed-meshheading:16677153-Male,
pubmed-meshheading:16677153-Mice,
pubmed-meshheading:16677153-Mice, Inbred C57BL,
pubmed-meshheading:16677153-Reactive Oxygen Species,
pubmed-meshheading:16677153-Receptors, Immunologic,
pubmed-meshheading:16677153-Signal Transduction,
pubmed-meshheading:16677153-Survival Rate,
pubmed-meshheading:16677153-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice.
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pubmed:affiliation |
Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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