|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3-4
|
|
pubmed:dateCreated |
2006-5-8
|
|
pubmed:abstractText |
A study is presented of the effect of the cAMP cascade on oxygen metabolism in mammalian cell cultures. Serum-starvation of the cell cultures resulted in depression of the forward NADH-ubiquinone oxidoreductase activity of complex I, decreased content of glutathione, and enhancement of the cellular level of H2O2. Depressed transcription of cytosolic Cu/Zn-SOD 1, mitochondrial glutathione peroxidase and catalase was also observed. Activation of the cAMP cascade reversed the depression of the activity of complex I and the accumulation of H2O2. The effect of cAMP involved the cAMP-dependent protein kinase.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1523-0864
|
|
pubmed:author |
pubmed-author:BellomoFF,
pubmed-author:BoffoliDD,
pubmed-author:CapitanioNN,
pubmed-author:CoccoTT,
pubmed-author:D'AprileAA,
pubmed-author:GaballoAA,
pubmed-author:PapaFF,
pubmed-author:PapaSS,
pubmed-author:PiccoliCC,
pubmed-author:SardanelliA MAM,
pubmed-author:ScaccoSS,
pubmed-author:ScrimaRR,
pubmed-author:SignorileAA
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
495-502
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16677093-Animals,
pubmed-meshheading:16677093-Catalase,
pubmed-meshheading:16677093-Cyclic AMP,
pubmed-meshheading:16677093-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:16677093-Cytosol,
pubmed-meshheading:16677093-Fibroblasts,
pubmed-meshheading:16677093-Free Radicals,
pubmed-meshheading:16677093-Glutathione Peroxidase,
pubmed-meshheading:16677093-Humans,
pubmed-meshheading:16677093-Hydrogen Peroxide,
pubmed-meshheading:16677093-Mice,
pubmed-meshheading:16677093-Mice, Inbred BALB C,
pubmed-meshheading:16677093-NIH 3T3 Cells,
pubmed-meshheading:16677093-Oxygen,
pubmed-meshheading:16677093-Reactive Oxygen Species,
pubmed-meshheading:16677093-Superoxide Dismutase
|
|
pubmed:articleTitle |
Regulation by the cAMP cascade of oxygen free radical balance in mammalian cells.
|
|
pubmed:affiliation |
Department of Medical Biochemistry, Biology and Physics, University of Bari, Bari, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
