Linked Life Data

16676512

Source:http://linkedlifedata.com/resource/pubmed/id/16676512

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2006-5-8
pubmed:abstractText
The lungs constitute an attractive route for the administration of insulin in view of their large surface area and the permeability for proteins. Inhaled insulin may greatly reduce the daily nuisance of subcutaneous injections for millions of patients. The acceptance of insulin therapy may therefore be increased, so that better metabolic control can be achieved. For optimal efficacy it is essential that the insulin be precipitated in the alveoli and it is precisely the reproducibility of this process that is variable and dependent upon a variety of factors. Thus, the properties of the particles, technique of respiration, administration system and the presence of pulmonary disease (smoking) all play a role. The pharmacokinetics make inhaled insulin suitable for preprandial administration: the absorption is very rapid, so that it can be taken a very short time before meals. The duration of action, however, is short, so that the use of long-acting insulin usually remains necessary. The biological availability of inhaled insulin is < 20%, so that the required dose is larger. The long-term effects of the intra-alveolar administration of insulin and its immunological consequences are still insufficiently clear, although no permanent negative effects have been demonstrated so far. Partly in view of the favourable pharmacodynamic properties, the use of inhaled insulin is an attractive therapeutic option, not only for the group of patients with a fear of injections but for all diabetics that require insulin therapy.
pubmed:commentsCorrections
pubmed:language
dut
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0028-2162
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
150
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
833-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Inhaled insulin: a new route in the optimisation of glucose regulation].
pubmed:affiliation
Twenteborg Ziekenhuis, afd Interne Geneeskunde, Almelo.
pubmed:publicationType
Journal Article, English Abstract, Review