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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-9-18
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pubmed:abstractText |
The class A macrophage scavenger receptor SR-AI/II is implicated as a pattern recognition receptor for innate immunity, but its functional role in lung defense has not been studied. We used mice genetically deficient in SR-AI/II and their wild-type C57BL/6 counterparts to investigate the contribution of this receptor to defense against pneumococcal infection and inhaled particles. SR-AI/II deficiency caused impaired phagocytosis of fluorescent bacteria in vivo, diminished clearance of live bacteria from the lungs, and substantially increased pneumonic inflammation. Survival studies also showed increased mortality in SR-AI/II-deficient mice with pneumococcal lung infection. Similarly, after challenge of the airways with TiO(2) particles, SR-AI/II-deficient mice showed increased proinflammatory cytokine levels in lung lavage fluid and a more pronounced neutrophilic inflammation. The data indicate that the lung macrophage class A scavenger receptor SR-AI/II contributes to innate defense against bacteria and inhaled particles.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16675784-10065621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16675784-10224290,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16675784-9069289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16675784-9149581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16675784-9218499,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16675784-9788476
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1044-1549
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
474-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16675784-Animals,
pubmed-meshheading:16675784-Disease Susceptibility,
pubmed-meshheading:16675784-Female,
pubmed-meshheading:16675784-Immunity, Innate,
pubmed-meshheading:16675784-Lung,
pubmed-meshheading:16675784-Macrophages, Alveolar,
pubmed-meshheading:16675784-Male,
pubmed-meshheading:16675784-Mice,
pubmed-meshheading:16675784-Mice, Inbred C57BL,
pubmed-meshheading:16675784-Mice, Knockout,
pubmed-meshheading:16675784-Phagocytosis,
pubmed-meshheading:16675784-Pneumonia, Pneumococcal,
pubmed-meshheading:16675784-Scavenger Receptors, Class A,
pubmed-meshheading:16675784-Titanium
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pubmed:year |
2006
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pubmed:articleTitle |
The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles.
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pubmed:affiliation |
Physiology Program, 665 Huntington Avenue, SPH-II, Room 221, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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