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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-10-31
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pubmed:abstractText |
Our goal was to establish versatile and high capacity assays to characterize activity and toxicity of chemotherapeutics. The major anti-cancer activity indicators of these agents included inhibition of proliferation and induction of apoptosis to cancer cells. In addition, cytotoxicity and myelosuppressive activity to normal cells were parameters to evaluate toxicity of these drugs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1056-8719
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
313-9
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pubmed:meshHeading |
pubmed-meshheading:16675273-Animal Testing Alternatives,
pubmed-meshheading:16675273-Antineoplastic Agents,
pubmed-meshheading:16675273-Apoptosis,
pubmed-meshheading:16675273-Breast,
pubmed-meshheading:16675273-Caspase 3,
pubmed-meshheading:16675273-Caspase 7,
pubmed-meshheading:16675273-Cell Line, Tumor,
pubmed-meshheading:16675273-Cell Proliferation,
pubmed-meshheading:16675273-Cell Survival,
pubmed-meshheading:16675273-Cells, Cultured,
pubmed-meshheading:16675273-Drug Evaluation, Preclinical,
pubmed-meshheading:16675273-Epithelial Cells,
pubmed-meshheading:16675273-Hematopoietic Stem Cells,
pubmed-meshheading:16675273-Humans
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pubmed:articleTitle |
Cell-based assays for profiling activity and safety properties of cancer drugs.
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pubmed:affiliation |
Department of Pharmacology, Berlex Biosciences, Richmond, CA 94804, USA. wei-wei_li@berlex.com
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pubmed:publicationType |
Journal Article
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