Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2006-5-4
pubmed:abstractText
Disturbance to early brain development is implicated in several neuropsychiatric disorders including autism, schizophrenia, and mental retardation. Epidemiological studies have indicated that the risk of developing these disorders is enhanced by prenatal maternal infection, presumably as a result of neurodevelopmental defects triggered by cytokine-related inflammatory events. Here, we demonstrate that the effects of maternal immune challenge between middle and late gestation periods in mice are dissociable in terms of fetal brain cytokine responses to maternal inflammation and the pathological consequences in brain and behavior. Specifically, the relative expression of pro- and anti-inflammatory cytokines in the fetal brains in response to maternal immune challenge may be an important determinant among other developmental factors for the precise pathological profile emerging in later life. Thus, the middle and late gestation periods correspond to two windows with differing vulnerability to adult behavioral dysfunction, brain neuropathology in early adolescence, and of the acute cytokine responses in the fetal brain.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3, http://linkedlifedata.com/resource/pubmed/chemical/Caspases, http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, Neuronal, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides, http://linkedlifedata.com/resource/pubmed/chemical/Polynucleotides, http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/doublecortin protein, http://linkedlifedata.com/resource/pubmed/chemical/poly(rI).poly(dC), http://linkedlifedata.com/resource/pubmed/chemical/reelin protein
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4752-62
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16672647-Analysis of Variance, pubmed-meshheading:16672647-Animals, pubmed-meshheading:16672647-Animals, Newborn, pubmed-meshheading:16672647-Behavior, Animal, pubmed-meshheading:16672647-Brain, pubmed-meshheading:16672647-Caspase 3, pubmed-meshheading:16672647-Caspases, pubmed-meshheading:16672647-Cell Adhesion Molecules, Neuronal, pubmed-meshheading:16672647-Cell Count, pubmed-meshheading:16672647-Cytokines, pubmed-meshheading:16672647-Embryo, Mammalian, pubmed-meshheading:16672647-Exploratory Behavior, pubmed-meshheading:16672647-Extracellular Matrix Proteins, pubmed-meshheading:16672647-Female, pubmed-meshheading:16672647-Gene Expression, pubmed-meshheading:16672647-Gene Expression Regulation, Developmental, pubmed-meshheading:16672647-Immunohistochemistry, pubmed-meshheading:16672647-Male, pubmed-meshheading:16672647-Mice, pubmed-meshheading:16672647-Microtubule-Associated Proteins, pubmed-meshheading:16672647-Motor Activity, pubmed-meshheading:16672647-Nerve Tissue Proteins, pubmed-meshheading:16672647-Neuropeptides, pubmed-meshheading:16672647-Polynucleotides, pubmed-meshheading:16672647-Pregnancy, pubmed-meshheading:16672647-Prenatal Exposure Delayed Effects, pubmed-meshheading:16672647-Reversal Learning, pubmed-meshheading:16672647-Serine Endopeptidases, pubmed-meshheading:16672647-Spatial Behavior, pubmed-meshheading:16672647-Time Factors
pubmed:year
2006
pubmed:articleTitle
The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology.
pubmed:affiliation
Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, CH-8603 Schwerzenbach, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't