| pubmed-article:16672337 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16672337 | lifeskim:mentions | umls-concept:C1517749 | lld:lifeskim |
| pubmed-article:16672337 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16672337 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16672337 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:16672337 | lifeskim:mentions | umls-concept:C1326539 | lld:lifeskim |
| pubmed-article:16672337 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:16672337 | lifeskim:mentions | umls-concept:C0279266 | lld:lifeskim |
| pubmed-article:16672337 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16672337 | pubmed:dateCreated | 2006-5-12 | lld:pubmed |
| pubmed-article:16672337 | pubmed:abstractText | The bone morphogenetic protein (BMP) signaling pathway is essential during gastrulation for the generation of ventral mesoderm, which makes it a challenge to define functions for this pathway at later stages of development. We have established an approach to disrupt BMP signaling specifically in lateral mesoderm during somitogenesis, by targeting a dominant-negative BMP receptor to Lmo2+ cells in developing zebrafish embryos. This results in expansion of hematopoietic and endothelial cells, while restricting the expression domain of the pronephric marker pax2.1. Expression of a constitutively active receptor and transplantation experiments were used to confirm that BMP signaling in lateral mesoderm restricts subsequent hemato-vascular development. The results show that the BMP signaling pathway continues to function after cells are committed to a lateral mesoderm fate, and influences subsequent lineage decisions by restricting hemato-vascular fate in favor of pronephric development. | lld:pubmed |
| pubmed-article:16672337 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16672337 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16672337 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16672337 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16672337 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16672337 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:16672337 | pubmed:author | pubmed-author:ZonLeonard... | lld:pubmed |
| pubmed-article:16672337 | pubmed:author | pubmed-author:ZhuHaoH | lld:pubmed |
| pubmed-article:16672337 | pubmed:author | pubmed-author:EvansToddT | lld:pubmed |
| pubmed-article:16672337 | pubmed:author | pubmed-author:GuptaSunnyS | lld:pubmed |
| pubmed-article:16672337 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16672337 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:16672337 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16672337 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16672337 | pubmed:pagination | 2177-87 | lld:pubmed |
| pubmed-article:16672337 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16672337 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16672337 | pubmed:articleTitle | BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. | lld:pubmed |
| pubmed-article:16672337 | pubmed:affiliation | Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. | lld:pubmed |
| pubmed-article:16672337 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16672337 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16672337 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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