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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-5-12
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pubmed:abstractText |
The bone morphogenetic protein (BMP) signaling pathway is essential during gastrulation for the generation of ventral mesoderm, which makes it a challenge to define functions for this pathway at later stages of development. We have established an approach to disrupt BMP signaling specifically in lateral mesoderm during somitogenesis, by targeting a dominant-negative BMP receptor to Lmo2+ cells in developing zebrafish embryos. This results in expansion of hematopoietic and endothelial cells, while restricting the expression domain of the pronephric marker pax2.1. Expression of a constitutively active receptor and transplantation experiments were used to confirm that BMP signaling in lateral mesoderm restricts subsequent hemato-vascular development. The results show that the BMP signaling pathway continues to function after cells are committed to a lateral mesoderm fate, and influences subsequent lineage decisions by restricting hemato-vascular fate in favor of pronephric development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonucleases, Type II...,
http://linkedlifedata.com/resource/pubmed/chemical/PAX2 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/SCEI protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/pax2a protein, zebrafish
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2177-87
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16672337-Animals,
pubmed-meshheading:16672337-Animals, Genetically Modified,
pubmed-meshheading:16672337-Biological Markers,
pubmed-meshheading:16672337-Bone Morphogenetic Protein Receptors,
pubmed-meshheading:16672337-Bone Morphogenetic Proteins,
pubmed-meshheading:16672337-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:16672337-Gene Expression Regulation, Developmental,
pubmed-meshheading:16672337-Hematopoiesis,
pubmed-meshheading:16672337-Kidney,
pubmed-meshheading:16672337-Mesoderm,
pubmed-meshheading:16672337-PAX2 Transcription Factor,
pubmed-meshheading:16672337-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:16672337-Signal Transduction,
pubmed-meshheading:16672337-Somites,
pubmed-meshheading:16672337-Stem Cells,
pubmed-meshheading:16672337-Time Factors,
pubmed-meshheading:16672337-Zebrafish,
pubmed-meshheading:16672337-Zebrafish Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis.
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pubmed:affiliation |
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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