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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-7-20
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pubmed:abstractText |
Therapeutic regulation of PPARdelta activity using selective agonists has been proposed for various disorders. However, the consequences of altered peroxisome proliferator-activated receptor delta (PPARdelta) activity in the context of intestinal tumourigenesis remain somewhat unclear. Contradictory evidence suggesting PPARdelta either attenuates or potentiates intestinal neoplasia. To further investigate the PPARdelta dependency of intestinal tumourigenesis, we have analysed the consequences of PPARdelta deficiency upon intestinal neoplasia occurring in mice with impaired mismatch DNA repair.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-10555149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-10602475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-10866668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-11087869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-11226285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-11237216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-11304699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-11306497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-11756685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-12447373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-12584176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-12705865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-14758356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-15048110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-15126355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-15150130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-15475963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-15480419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-15860371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-15949697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-15978581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-16021179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-16098614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-16618765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-8145827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-8673133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16672050-9500552
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16672050-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:16672050-Adenoma,
pubmed-meshheading:16672050-Animals,
pubmed-meshheading:16672050-Base Pair Mismatch,
pubmed-meshheading:16672050-Carrier Proteins,
pubmed-meshheading:16672050-DNA Repair,
pubmed-meshheading:16672050-Intestinal Neoplasms,
pubmed-meshheading:16672050-Mice,
pubmed-meshheading:16672050-Mice, Inbred C57BL,
pubmed-meshheading:16672050-Mice, Knockout,
pubmed-meshheading:16672050-Nuclear Proteins,
pubmed-meshheading:16672050-PPAR delta,
pubmed-meshheading:16672050-Survival Analysis
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pubmed:year |
2006
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pubmed:articleTitle |
PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.
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pubmed:affiliation |
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF103US, UK. reedkr@cf.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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