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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-5-17
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pubmed:abstractText |
Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respiratory motion. Data from phantom studies and a reproducibility study in solid human tumours are presented. The reproducibility study showed a coefficient of variation (CoV) of 19.1% for K(trans) and 15.8% for the initial area under the contrast enhancement curve (IAUC). This was improved to 16 and 13.9% if tumours of diameter less than 3 cm were excluded. The individual repeatability (the range within which individual measurements are expected to fall) was 30.6% for K(trans) and 26.5% for IAUC for tumours greater than 3 cm diameter. This approach to DCE-MRI image acquisition can be performed with standard clinical scanners, and data analysis is straightforward. For treatment trials with 10 patients in a cohort, the CoV implies that the method would be sensitive to a treatment effect of greater than 18%. The individual repeatability is well inside the 40% change shown to be important in clinical studies using this DCE-MRI technique.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-10508280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-10508281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-10508284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-10508285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-10508286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-10508287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-10581502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-11870909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-12359857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-12807936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-14517187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-15173071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-15474341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-15709211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-15867205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-15870830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-1947084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-2062210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-2319937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-8843376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-9170043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-9212107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16670720-9814771
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1420-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16670720-Angiogenesis Inhibitors,
pubmed-meshheading:16670720-Area Under Curve,
pubmed-meshheading:16670720-Colorectal Neoplasms,
pubmed-meshheading:16670720-Contrast Media,
pubmed-meshheading:16670720-Drug Monitoring,
pubmed-meshheading:16670720-Humans,
pubmed-meshheading:16670720-Image Processing, Computer-Assisted,
pubmed-meshheading:16670720-Liver Neoplasms,
pubmed-meshheading:16670720-Lung Neoplasms,
pubmed-meshheading:16670720-Magnetic Resonance Imaging,
pubmed-meshheading:16670720-Phantoms, Imaging,
pubmed-meshheading:16670720-Phthalazines,
pubmed-meshheading:16670720-Pyridines,
pubmed-meshheading:16670720-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:16670720-Reproducibility of Results
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pubmed:year |
2006
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pubmed:articleTitle |
A simple, reproducible method for monitoring the treatment of tumours using dynamic contrast-enhanced MR imaging.
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pubmed:affiliation |
Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK. bm11@le.ac.uk
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pubmed:publicationType |
Journal Article,
Clinical Trial, Phase I
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