rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1992-5-6
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pubmed:abstractText |
Response of the ATP, ubiquitin-dependent system during the enhanced degradation of erythrocyte maturation conforms to the general regulatory features common to several similar but unrelated systems. In erythroid cells enhanced degradation follows three phases: (1) Onset of degradation characterized by an increase in the intracellular concentration of free and conjugated ubiquitin, brought about by reduction in mean cell volume; (2) Active enhanced degradation during cellular remodeling; and (3) Loss of activity as a consequence of spontaneous inactivation of components required for ubiquitin conjugation. The extent of degradative remodeling is probably functionally limited by the loss of these critical ligation enzymes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:issn |
0065-2598
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
307
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-205
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1666814-Adenosine Triphosphate,
pubmed-meshheading:1666814-Animals,
pubmed-meshheading:1666814-Blood Proteins,
pubmed-meshheading:1666814-Cell Death,
pubmed-meshheading:1666814-Cell Differentiation,
pubmed-meshheading:1666814-Endopeptidases,
pubmed-meshheading:1666814-Erythrocytes,
pubmed-meshheading:1666814-Erythropoiesis,
pubmed-meshheading:1666814-Models, Biological,
pubmed-meshheading:1666814-Protein Processing, Post-Translational,
pubmed-meshheading:1666814-Proteins,
pubmed-meshheading:1666814-Rabbits,
pubmed-meshheading:1666814-Reticulocytes,
pubmed-meshheading:1666814-Ubiquitins
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pubmed:year |
1991
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pubmed:articleTitle |
Ubiquitin-mediated processes in erythroid cell maturation.
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pubmed:affiliation |
Department of Biochemistry, Medical College of Wisconsin, Milwaukee.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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