Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1992-4-24
pubmed:abstractText
(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA], (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-2,6-diaminopurine [(S)-HPMPDAP], cyclic (S)-HPMPA [(S)-cHPMPA], 9-(2-phosphonylmethoxyethoxyethyl)-2,6-diaminopurine (PMEDAP), and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] were examined for their inhibitory effects on Epstein-Barr virus (EBV) replication. The 50% effective concentrations for inhibition of viral DNA replication were 0.16, 0.03, 2.0, 1.5, and 0.08 microM for PMEDAP, (S)-HPMPC, (S)-HPMPDAP, (S)-cHPMPA, and (S)-HPMPA, respectively. The relative efficacies based on the in vitro therapeutic index was (S)-HPMPC (5,000) greater than PMEDAP (1,000) = (S)-HPMPA (1,000) greater than (S)-cHPMPA (136) greater than (S)-HPMPDAP (78). Certain ratios of combinations of (S)-HPMPC with 3'-azido-3'-deoxythymidine produced a synergistic inhibitory effect on EBV genome replication, but others exhibited an antagonistic effect. These results indicate that this series of acyclic nucleoside phosphonate analogs, and in particular (S)-HPMPC, are potent and selective anti-EBV agents in vitro.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-1850046, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-2409414, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-2479334, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-2536780, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-2823699, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-2826784, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-2847636, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-3009638, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-3451698, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-3762696, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-6093395, http://linkedlifedata.com/resource/pubmed/commentcorrection/1666500-6321799
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2440-3
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication.
pubmed:affiliation
Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.