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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1992-4-24
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pubmed:abstractText |
The inhibition of DNA synthesis by sparfloxacin; accumulation of sparfloxacin into members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and staphylococci; induction of recA in Escherichia coli; and the optimum bactericidal concentration (OBC) were measured, and killing kinetics at the OBC were estimated. The OBC and maximum recA-inducing concentration in E. coli were both 1 microgram of sparfloxacin per ml. Accumulation was rapid; two- to threefold more sparfloxacin than ciprofloxacin accumulated in staphylococci and more sparfloxacin accumulated in staphylococci than in gram-negative bacteria. Laboratory mutants with decreased susceptibilities to quinolones alone or multiply resistant were selected from the Enterobacteriaceae and Staphylococcus aureus by using sparfloxacin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-1708224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-1963286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-1963290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2024969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2039202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2039209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2079449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2081717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2110938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2127348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2168142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2285304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2540707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2658782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-2679373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-3010850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-3015000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-3056251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-3532944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1666499-4570289
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:geneSymbol |
recA
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2423-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1666499-Anti-Bacterial Agents,
pubmed-meshheading:1666499-Ciprofloxacin,
pubmed-meshheading:1666499-DNA, Bacterial,
pubmed-meshheading:1666499-DNA Probes,
pubmed-meshheading:1666499-Drug Resistance, Microbial,
pubmed-meshheading:1666499-Enterobacteriaceae,
pubmed-meshheading:1666499-Fluoroquinolones,
pubmed-meshheading:1666499-Gram-Negative Bacteria,
pubmed-meshheading:1666499-Gram-Positive Bacteria,
pubmed-meshheading:1666499-Mutation,
pubmed-meshheading:1666499-Phenotype,
pubmed-meshheading:1666499-Pseudomonas aeruginosa,
pubmed-meshheading:1666499-Quinolones
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pubmed:year |
1991
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pubmed:articleTitle |
Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria.
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pubmed:affiliation |
Antimicrobial Agents Research Group, Medical School, University of Birmingham, United Kingdom.
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pubmed:publicationType |
Journal Article
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