Linked Life Data

1666422

Source:http://linkedlifedata.com/resource/pubmed/id/1666422

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pubmed-article:1666422pubmed:abstractTextTiamulin with an IC50 of 1.7 x 10(-6) M inhibited both the rapid and sustained contractions induced by hyperosmotically added 60 mM K+ (Hyper 60 K+) without changing the membrane potential in the intestinal muscle. Tiamulin inhibition (2 x 10(-6)-2 x 10(-5) M) of the Ca(2+)-induced contraction in depolarized muscle was competitively antagonized by raising external Ca2+. Tiamulin (2 x 10(-5) M) slightly affected the Hyper 60 K(+)-induced phasic contraction under hypoxia and the carbachol-induced phasic contraction. Moreover, tiamulin (2 x 10(-5) M) inhibited the Hyper 60 K(+)-induced contraction with decreasing [Ca2+]cyt level. Although the inhibitory effect of 10(-7)-10(-5) M monesin, an inhibitor of mitochondrial respiration, on the Hyper 60 K(+)-induced contraction was reduced under hypoxia, the effect of tiamulin (2 x 10(-7)-2 x 10(-4) M) was not modified. Tiamulin changed neither the intracellular Na+ and K+ content of the depolarized muscle nor the Ca(2+)-induced contraction in the chemically skinned preparations. These results suggest that the inhibitory action of tiamulin on the Hyper 60 K(+)-induced tonic contraction is possibly due to the competitive inhibition of Ca2+ entry through the voltage-dependent Ca2+ channel of the intestinal smooth muscle cell.lld:pubmed
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pubmed-article:1666422pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1666422pubmed:year1991lld:pubmed
pubmed-article:1666422pubmed:articleTitleThe inhibitory effect of tiamulin on high K(+)-induced contraction in guinea pig intestinal smooth muscle.lld:pubmed
pubmed-article:1666422pubmed:affiliationDivision of Veterinary Pharmacology, Nippon Veterinary and Animal Science University, Tokyo, Japan.lld:pubmed
pubmed-article:1666422pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1666422pubmed:publicationTypeComparative Studylld:pubmed