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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1992-4-20
|
| pubmed:abstractText |
Structural variants of nuclear hormone receptors have been found in tumour tissues. Experimental evidence suggests two ways in which these variants may have oncogenic potential: 1. by suppressing the action of the normal hormone receptor, thereby acting as dominant negative oncogenes; 2. by activating hormone-responsive genes in a hormone-independent manner. These mechanisms may not only contribute to oncogenesis but also to the development of hormone resistance in tumours, e.g. breast and prostate cancer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0001-5598
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
125 Suppl 1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
48-53
|
| pubmed:dateRevised |
2005-11-16
|
| pubmed:meshHeading |
pubmed-meshheading:1666242-Cell Nucleus,
pubmed-meshheading:1666242-Drug Resistance,
pubmed-meshheading:1666242-Hormones,
pubmed-meshheading:1666242-Humans,
pubmed-meshheading:1666242-Mutation,
pubmed-meshheading:1666242-Neoplasms,
pubmed-meshheading:1666242-Oncogenes,
pubmed-meshheading:1666242-Receptors, Cell Surface,
pubmed-meshheading:1666242-Receptors, Estrogen,
pubmed-meshheading:1666242-Transcription, Genetic
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Nuclear hormone receptor variants: their role in malignancy and progression to hormone resistance in cancer.
|
| pubmed:affiliation |
Division of Tumour Biology, The Netherlands Cancer Institute.
|
| pubmed:publicationType |
Journal Article,
Review
|