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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-4-13
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pubmed:abstractText |
Cumulative contractile response curves to neurokinin A (NKA) and neuropeptide gamma (NP gamma) were obtained in human isolated bronchus, in the presence of phosphoramidon 10 microM. NP gamma was approximately 10-fold more potent than NKA (pD2 values 8.6 +/- 0.4 and 7.3 +/- 0.3 respectively, n = 6; P less than 0.01). The NK1-selective agonist [Sar9, Met(O2)11]-SP and the NK3 selective agonist senktide produced negligible contraction. Response curves to NP gamma and NKA were unaffected by the NK2 subtype-selective antagonist MDL 29913 at 2 microM, but NP gamma-induced contraction was markedly inhibited by 20 microM MDL 29,913. Thus NP gamma is the most potent tachykinin in human isolated bronchus and its effects are mediated at a receptor which is not of the 'classical' NK2 subtype found in hamster urinary bladder.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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|
pubmed:issn |
0143-4179
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1665897-Amino Acid Sequence,
pubmed-meshheading:1665897-Bronchi,
pubmed-meshheading:1665897-Humans,
pubmed-meshheading:1665897-Molecular Sequence Data,
pubmed-meshheading:1665897-Muscle Contraction,
pubmed-meshheading:1665897-Neurokinin A,
pubmed-meshheading:1665897-Peptide Fragments,
pubmed-meshheading:1665897-Peptides, Cyclic,
pubmed-meshheading:1665897-Receptors, Neurotransmitter,
pubmed-meshheading:1665897-Receptors, Tachykinin,
pubmed-meshheading:1665897-Tachykinins
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pubmed:year |
1991
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pubmed:articleTitle |
Neuropeptide gamma, the most potent contractile tachykinin in human isolated bronchus, acts via a 'non-classical' NK2 receptor.
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pubmed:affiliation |
Department of Pharmacology, University of Sydney, NSW, Australia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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