Linked Life Data

1665799

Source:http://linkedlifedata.com/resource/pubmed/id/1665799

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pubmed-article:1665799pubmed:abstractTextLesioning of dopamine neurons by injection of 6-hydroxydopamine into the nucleus accumbens blocked the increased rearing activity measured in the open-field and induced by injection into the ventral tegmental area of: [R)-3-(N-hydroxylcarboxamido-2-benzyl-propanoyl)-L-alanine), kelatorphan (complete inhibitor of enkephalin catabolism) or by (Tyr-D-Ser(OtBu)-Gly-Phe-Leu-Thr(OtBu)): BUBU (selective delta agonist) but not the hypolocomotion evoked by the mu agonist (Tyr-D-Ala-Gly-N(Me)-Phe-Glyol): DAMGO. This suggests the involvement of different neuronal pathways in mu and delta effects.lld:pubmed
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pubmed-article:1665799pubmed:articleTitleLesion of dopamine mesolimbic neurons blocks behavioral effects induced by the endogenous enkephalins but not by a mu-opioid receptor agonist.lld:pubmed
pubmed-article:1665799pubmed:affiliationPharmacochimie Moléculaire, INSERM U266, CNRS UA498, UFR des Sciences Pharmaceutiques et Biologiques, Paris, France.lld:pubmed
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