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rdf:type |
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lifeskim:mentions |
umls-concept:C0004927,
umls-concept:C0013030,
umls-concept:C0014298,
umls-concept:C0027882,
umls-concept:C0066908,
umls-concept:C0205227,
umls-concept:C0205263,
umls-concept:C0221198,
umls-concept:C0243192,
umls-concept:C1280500,
umls-concept:C1533157,
umls-concept:C1555903
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pubmed:issue |
3
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pubmed:dateCreated |
1992-4-15
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pubmed:abstractText |
Lesioning of dopamine neurons by injection of 6-hydroxydopamine into the nucleus accumbens blocked the increased rearing activity measured in the open-field and induced by injection into the ventral tegmental area of: [R)-3-(N-hydroxylcarboxamido-2-benzyl-propanoyl)-L-alanine), kelatorphan (complete inhibitor of enkephalin catabolism) or by (Tyr-D-Ser(OtBu)-Gly-Phe-Leu-Thr(OtBu)): BUBU (selective delta agonist) but not the hypolocomotion evoked by the mu agonist (Tyr-D-Ala-Gly-N(Me)-Phe-Glyol): DAMGO. This suggests the involvement of different neuronal pathways in mu and delta effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/kelatorphan,
http://linkedlifedata.com/resource/pubmed/chemical/tyrosyl-seryl(O-t-butyl)-glycyl-phen...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-2999
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
209
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-71
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1665799-Amino Acid Sequence,
pubmed-meshheading:1665799-Analgesics,
pubmed-meshheading:1665799-Animals,
pubmed-meshheading:1665799-Behavior, Animal,
pubmed-meshheading:1665799-Dipeptides,
pubmed-meshheading:1665799-Dopamine,
pubmed-meshheading:1665799-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
pubmed-meshheading:1665799-Enkephalins,
pubmed-meshheading:1665799-Limbic System,
pubmed-meshheading:1665799-Male,
pubmed-meshheading:1665799-Molecular Sequence Data,
pubmed-meshheading:1665799-Motor Activity,
pubmed-meshheading:1665799-Neurons,
pubmed-meshheading:1665799-Nucleus Accumbens,
pubmed-meshheading:1665799-Oligopeptides,
pubmed-meshheading:1665799-Oxidopamine,
pubmed-meshheading:1665799-Rats,
pubmed-meshheading:1665799-Rats, Inbred Strains,
pubmed-meshheading:1665799-Receptors, Opioid,
pubmed-meshheading:1665799-Receptors, Opioid, delta,
pubmed-meshheading:1665799-Receptors, Opioid, mu,
pubmed-meshheading:1665799-Tegmentum Mesencephali
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pubmed:year |
1991
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pubmed:articleTitle |
Lesion of dopamine mesolimbic neurons blocks behavioral effects induced by the endogenous enkephalins but not by a mu-opioid receptor agonist.
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pubmed:affiliation |
Pharmacochimie Moléculaire, INSERM U266, CNRS UA498, UFR des Sciences Pharmaceutiques et Biologiques, Paris, France.
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pubmed:publicationType |
Journal Article
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