Source:http://linkedlifedata.com/resource/pubmed/id/16656356
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2010-6-29
|
| pubmed:abstractText |
The accumulation of labeled phosphorus into newly synthesized nucleic acids or peanut cotyledon slices incubated with chloramphenicol, puromycin, or 2,4-dichlorophenoxyacetic acid (2,4-D) was reduced. Promotion of nucleic acid synthesis was not noted by any of these chemicals. Chloramphenicol completely inhibited the synthesis of the DNA-RNA fraction at 1.25 x 10(-3)m while soluble and ribosomal RNA was inhibited by 70% and 80%, respectively. At the same concentration messenger RNA was inhibited by only 40%. These effects suggest that chloramphenicol inhibit nucleic acid synthesis in peanut cotyledons in a differential manner. Similar results were noted for DNA at low concentrations of 2,4-D. However, at high concentrations of 2,4-D, DNA as well as RNA fractions were inhibited in a similar manner at a given concentration. Puromycin did not differentially inhibit nucleic acid synthesis except at 2 x 10(-3)m where DNA was least inhibited.Nondifferential inhibition suggests that a common site or precursor pool essential for the synthesis of all nucleic acid fractions is altered. Differential inhibition may be due to the interference with a specific rate-limiting step, directly or indirectly, in the formation of a particular nucleic acid.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-13032100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-13860529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-13862509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-13990265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-14002462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-14066614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-14067087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-14166766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-14202463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-14324808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-14420563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-14460744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-16655812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16656356-16656131
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0032-0889
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
919-22
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| pubmed:dateRevised |
2010-9-14
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| pubmed:year |
1966
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| pubmed:articleTitle |
Effects of protein inhibitors and auxin on nucleic Acid metabolism in peanut cotyledons.
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| pubmed:affiliation |
Department of Horticulture, Purdue University, Lafayette, Indiana.
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| pubmed:publicationType |
Journal Article
|