|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1992-4-2
|
|
pubmed:abstractText |
Interleukin 4 (IL-4) is a product of activated T cells and mast cells with effects on immunologic and hematopoietic processes. We now report that IL-4 inhibits the formation of osteoclasts from murine bone marrow cells cocultured with stromal cells. Numerous (3,000-4,000 cells/2 cm2) tartrate-resistant acid-phosphatase-positive multinucleated cells with the capacity to generate cAMP in response to salmon calcitonin (ED50 = 10(-10) M) developed within 10-12 days of culture. IL-4 (ID50 = 10 U/ml) inhibited osteoclast generation in doses similar to those that induce proliferation of IL-4-responsive T cells. Additionally, the rat antimurine IL-4 monoclonal antibody 11B11 antagonizes the IL-4-inhibitory effect on osteoclast formation. These results suggest that IL-4 impedes agonist-induced in vitro bone resorption by inhibiting osteoclastogenesis.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0730-2312
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
272-7
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:1665152-Animals,
pubmed-meshheading:1665152-Antibodies, Monoclonal,
pubmed-meshheading:1665152-Biological Markers,
pubmed-meshheading:1665152-Bone Marrow,
pubmed-meshheading:1665152-Bone Marrow Cells,
pubmed-meshheading:1665152-Bone Remodeling,
pubmed-meshheading:1665152-Calcitonin,
pubmed-meshheading:1665152-Cell Differentiation,
pubmed-meshheading:1665152-Cell Division,
pubmed-meshheading:1665152-Cells, Cultured,
pubmed-meshheading:1665152-Cyclic AMP,
pubmed-meshheading:1665152-Interleukin-4,
pubmed-meshheading:1665152-Lymphocyte Activation,
pubmed-meshheading:1665152-Mice,
pubmed-meshheading:1665152-Osteoclasts,
pubmed-meshheading:1665152-T-Lymphocytes
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Interleukin 4 inhibits murine osteoclast formation in vitro.
|
|
pubmed:affiliation |
Department of Pathology, Jewish Hospital of St. Louis, Washington University, Missouri 63110.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
