Linked Life Data

1664975

Source:http://linkedlifedata.com/resource/pubmed/id/1664975

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-3-24
pubmed:abstractText
The function of the microtubules (MTs) beneath the postsynaptic membrane was studied in the isolated non-uniform stretched muscle preparation of rat diaphragm with the use of colchicine. After exposure to this drug, the amplitude of miniature endplate potential (MEPP), the mean quantal contents and mean amplitude of endplate potentials (EPPs) elicited by 10 Hz and 50 Hz stimulation and the amplitude of acetylcholine potentials (AChP) were decreased significantly, but the frequency of MEPP, membrane potential and the time course of EPP and AChP remained unchanged. These results indicate that colchicine suppresses the responses of acetylcholine receptors (AChR). No such effects were observed with colchicine's isomer lumicolchicine. It is suggested that the MTs beneath the postsynaptic membrane may be involved in the responsive process of AChR.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0371-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
236-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Effect of colchicine on rat neuromuscular transmission].
pubmed:affiliation
Department of Physiology, First Medical College of PLA, Guangzhou.
pubmed:publicationType
Journal Article, In Vitro, English Abstract