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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-5-29
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pubmed:abstractText |
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
729-31
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16648847-Animals,
pubmed-meshheading:16648847-Antidepressive Agents,
pubmed-meshheading:16648847-Anxiety,
pubmed-meshheading:16648847-Behavior, Animal,
pubmed-meshheading:16648847-Bromodeoxyuridine,
pubmed-meshheading:16648847-Cell Division,
pubmed-meshheading:16648847-Cell Proliferation,
pubmed-meshheading:16648847-Dentate Gyrus,
pubmed-meshheading:16648847-Environment, Controlled,
pubmed-meshheading:16648847-Feeding Behavior,
pubmed-meshheading:16648847-Habituation, Psychophysiologic,
pubmed-meshheading:16648847-Maze Learning,
pubmed-meshheading:16648847-Memory Disorders,
pubmed-meshheading:16648847-Mice,
pubmed-meshheading:16648847-Neuronal Plasticity,
pubmed-meshheading:16648847-Neurons,
pubmed-meshheading:16648847-Stem Cells,
pubmed-meshheading:16648847-X-Rays
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pubmed:year |
2006
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pubmed:articleTitle |
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment.
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pubmed:affiliation |
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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