|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-5-1
|
|
pubmed:abstractText |
We have examined gene expression in multipotent neural precursor cells (NPCs) derived from human fetal (f) brain tissue and compared its expression profiles with embryonic stem (ESC) cells, embryoid body cell (EBC), and astrocyte precursors using the technique of massively parallel signature sequencing (MPSS). Gene expression profiles show that fNPCs express core neural stem cells markers and share expression profiles with astrocyte precursor cells (APCs) rather than ESC or EBC. Gene expression analysis shows that fNPCs differ from other adult stem and progenitor cells in their marker expression and activation of specific functional networks such as the transforming growth factorbeta (TGFbeta) and Notch signaling pathways. In addition, our results allow us to identify novel genes expressed in fNPCs and provide a detailed profile of fNPCs.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1547-3287
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
232-44
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16646669-Adult,
pubmed-meshheading:16646669-Astrocytes,
pubmed-meshheading:16646669-Brain,
pubmed-meshheading:16646669-Cell Cycle Proteins,
pubmed-meshheading:16646669-Cells, Cultured,
pubmed-meshheading:16646669-Chromosome Mapping,
pubmed-meshheading:16646669-Endoderm,
pubmed-meshheading:16646669-Fetus,
pubmed-meshheading:16646669-Gene Expression Profiling,
pubmed-meshheading:16646669-Gene Expression Regulation, Developmental,
pubmed-meshheading:16646669-Glial Fibrillary Acidic Protein,
pubmed-meshheading:16646669-Humans,
pubmed-meshheading:16646669-Immunohistochemistry,
pubmed-meshheading:16646669-Mesoderm,
pubmed-meshheading:16646669-Multipotent Stem Cells,
pubmed-meshheading:16646669-Nerve Growth Factors,
pubmed-meshheading:16646669-Neurons,
pubmed-meshheading:16646669-S100 Proteins,
pubmed-meshheading:16646669-Signal Transduction,
pubmed-meshheading:16646669-Stem Cells
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Massively parallel signature sequencing profiling of fetal human neural precursor cells.
|
|
pubmed:affiliation |
Stem Cell Biology Unit/Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
|
