Linked Life Data

16646590

Source:http://linkedlifedata.com/resource/pubmed/id/16646590

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-5-1
pubmed:abstractText
Atrial fibrillation (AF) is the most common arrhythmia in humans. AF is accompanied by a remodeling process which changes the electrophysiology of the cells and the gap junctional communication within the tissue. Gap junctions, forming communicating channels between neighboring cells, and their specific geometric arrangement seem to contribute to the initiation of AF within the pulmonary veins as well as to the stabilization of AF providing a heterogeneous biophysical network of cells enabling multiple wavelets. These tissue changes are accompanied by fibrosis and changes in the expression levels of Cx43 and Cx40, probably depending on the underlying diseases or the animal model used. New studies point to a modulating role of angiotensin II in this process and a possible therapeutic role for ACE inhibitors or AT(1) antagonists.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2326
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-74
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Role of connexins in atrial fibrillation.
pubmed:affiliation
Klinik für Herzchirurgie, Herzzentrum, Universität Leipzig, Leipzig, Germany. dhes@medizin.uni-leipzig.de
pubmed:publicationType
Journal Article, Review