Source:http://linkedlifedata.com/resource/pubmed/id/16645724
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| Predicate | Object |
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| rdf:type | |
| lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0031640,
umls-concept:C0034538,
umls-concept:C0039194,
umls-concept:C0174680,
umls-concept:C0205263,
umls-concept:C0221920,
umls-concept:C0521447,
umls-concept:C1149866,
umls-concept:C1314939,
umls-concept:C1412691,
umls-concept:C1417697,
umls-concept:C1521761,
umls-concept:C1553039,
umls-concept:C1849508,
umls-concept:C1879547
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| pubmed:issue |
1-2
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| pubmed:dateCreated |
2006-7-13
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| pubmed:abstractText |
The results from animal studies have shown that mouse skin is highly susceptible to both ionizing radiation and benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE). Previous studies have also indicated that cyclin D1 plays a crucial role in controlling cell proliferation and tumorigenesis. We, therefore, investigated here the effect of ionizing radiation and B[a]PDE on cyclin D1 transcription and potential involvement of NFAT3 in regulation of cyclin D1 transcription in mouse epidermal Cl 41 cells. We found that B[a]PDE exposure induced a high level of NFAT activation and cyclin D1 transcription in mouse epidermal Cl 41 cells. Ionizing radiation exhibited an enhancement for NFAT activation and cyclin D1 induction by B[a]PDE, even though ionizing radiation by itself had only a marginal effect. By stably knockdown of NFAT3 protein expression using specific NFAT3 small interfering RNA (siRNA), we found that cyclin D1 induction by B[a]PDE or B[a]PDE plus ionizing radiation was dramatically impaired. These results indicate that ionizing radiation is able to enhance cyclin D1 transcription induced by B[a]PDE, and NFAT3 is involved in the regulation of cyclin D1 transcription by B[a]PDE or B[a]PDE plus ionizing radiation.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0300-8177
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
287
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
117-25
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| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:16645724-7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide,
pubmed-meshheading:16645724-Animals,
pubmed-meshheading:16645724-Cell Line,
pubmed-meshheading:16645724-Cyclin D1,
pubmed-meshheading:16645724-Epidermis,
pubmed-meshheading:16645724-Gene Expression Regulation,
pubmed-meshheading:16645724-Mice,
pubmed-meshheading:16645724-NFATC Transcription Factors,
pubmed-meshheading:16645724-Radiation, Ionizing,
pubmed-meshheading:16645724-Transcription, Genetic
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| pubmed:year |
2006
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| pubmed:articleTitle |
Involvement of nuclear factor of activated T cells 3 (NFAT3) in cyclin D1 induction by B[a]PDE or B[a]PDE and ionizing radiation in mouse epidermal Cl 41 cells.
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| pubmed:affiliation |
Department of Etiology, Fourth Military Medical University, 17 Chunglexi Road, Xi'an, Shaanxi, 770032, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|