Source:http://linkedlifedata.com/resource/pubmed/id/16644713
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2006-4-28
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pubmed:abstractText |
Adiponectin is an adipocyte-derived hormone that has shown anti-inflammatory and antiatherogenic effects. We assessed the associations of variants in the adiponectin gene (ADIPOQ) with circulating adiponectin levels and cardiovascular risk among women with type 2 diabetes. Of 989 diabetic women from the Nurses' Health Study, 285 developed cardiovascular disease (CVD) during follow-up through 2000. We genotyped five ADIPOQ polymorphisms in the CVD case and control subjects. A promoter polymorphism -11365C-->G was significantly associated with lower plasma adiponectin levels (P = 0.004). The homozygotes of allele -4034C were significantly associated with approximately 60% increased cardiovascular risk (odds ratio 1.62 [95% CI 1.07-2.45]). Adjustment for age, BMI, and other covariates did not appreciably change the associations. In addition, a common haplotype possessing allele +276T (CAATT) was associated with a significantly lower CVD risk than the most common haplotype (CAATG) (0.70 [0.50-0.98]). In our meta-analysis of 827 CVD case and 1,887 CVD-free control subjects, polymorphism +276G-->T was significantly associated with approximately 45% (20-62%) decreased CVD risk under a recessive inheritance mode in diabetic patients. In conclusion, ADIPOQ promoter polymorphism -11365C-->G was associated with plasma adiponectin levels, whereas polymorphisms -4034A-->C and +276G-->T were associated with CVD risk in diabetic patients.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/CA 87969,
http://linkedlifedata.com/resource/pubmed/grant/DK 58845,
http://linkedlifedata.com/resource/pubmed/grant/HL 34594,
http://linkedlifedata.com/resource/pubmed/grant/HL 65582,
http://linkedlifedata.com/resource/pubmed/grant/HL 71981,
http://linkedlifedata.com/resource/pubmed/grant/P30 DK040561-11
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-1797
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1512-6
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pubmed:dateRevised |
2011-10-19
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pubmed:meshHeading |
pubmed-meshheading:16644713-Adiponectin,
pubmed-meshheading:16644713-Adult,
pubmed-meshheading:16644713-Cardiovascular Diseases,
pubmed-meshheading:16644713-Diabetes Mellitus, Type 2,
pubmed-meshheading:16644713-Diabetic Angiopathies,
pubmed-meshheading:16644713-Female,
pubmed-meshheading:16644713-Genetic Variation,
pubmed-meshheading:16644713-Humans,
pubmed-meshheading:16644713-Middle Aged,
pubmed-meshheading:16644713-Polymorphism, Single Nucleotide,
pubmed-meshheading:16644713-Promoter Regions, Genetic,
pubmed-meshheading:16644713-Reference Values
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pubmed:year |
2006
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pubmed:articleTitle |
Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes.
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pubmed:affiliation |
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. nhlqi@channing.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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