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pubmed-article:16644217pubmed:abstractTextSeveral potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO(2) and CF(3)) of the 4-aryl group led to active compounds. In two cases racemates were resolved and the S enantiomers shown to have higher potencies.lld:pubmed
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pubmed-article:16644217pubmed:articleTitleIdentification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4.lld:pubmed
pubmed-article:16644217pubmed:affiliationMedicinal Chemistry, Millennium Pharmaceuticals, Inc., 40 Landsdowne St., Cambridge, MA 02139, USA. chris.blackburn@mpi.comlld:pubmed
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