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pubmed-article:16643366pubmed:abstractTextThe occurrence of early afterdepolarizations (EADs) has been related to the incidence of torsades de pointes in drug-induced long QT (LQT). The generation of EADs may be facilitated by Ca(2+)/calmodulin-dependent protein kinase II (CaM kinase).lld:pubmed
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pubmed-article:16643366pubmed:articleTitleCalmodulin antagonist W-7 prevents sparfloxacin-induced early afterdepolarizations (EADs) in isolated rabbit purkinje fibers: importance of beat-to-beat instability of the repolarization.lld:pubmed
pubmed-article:16643366pubmed:affiliationCardiovascular Safety Research, Johnson & Johnson Pharmaceutical Research & Development, a Division of Janssen Pharmaceutica N.V. B-2340, Beerse, Belgium. hlu@prdbe.jnj.comlld:pubmed
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