|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2006-4-28
|
|
pubmed:abstractText |
The occurrence of early afterdepolarizations (EADs) has been related to the incidence of torsades de pointes in drug-induced long QT (LQT). The generation of EADs may be facilitated by Ca(2+)/calmodulin-dependent protein kinase II (CaM kinase).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1045-3873
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
415-22
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16643366-Animals,
pubmed-meshheading:16643366-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:16643366-Electrophysiologic Techniques, Cardiac,
pubmed-meshheading:16643366-Enzyme Inhibitors,
pubmed-meshheading:16643366-Female,
pubmed-meshheading:16643366-Fluoroquinolones,
pubmed-meshheading:16643366-Heart Rate,
pubmed-meshheading:16643366-Purkinje Fibers,
pubmed-meshheading:16643366-Rabbits,
pubmed-meshheading:16643366-Sulfonamides,
pubmed-meshheading:16643366-Torsades de Pointes
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Calmodulin antagonist W-7 prevents sparfloxacin-induced early afterdepolarizations (EADs) in isolated rabbit purkinje fibers: importance of beat-to-beat instability of the repolarization.
|
|
pubmed:affiliation |
Cardiovascular Safety Research, Johnson & Johnson Pharmaceutical Research & Development, a Division of Janssen Pharmaceutica N.V. B-2340, Beerse, Belgium. hlu@prdbe.jnj.com
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
|
