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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
1992-3-13
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pubmed:abstractText |
We investigated the hypertensive changes in renal arteries isolated from 21-week-old spontaneously hypertensive rats (SHR), and from age-matched normotensive Wistar-Kyoto rats (WKY). The maximum contraction of renal arteries from SHR in response to norepinephrine (NE), serotonin (5-HT) and KCl was greater than that of arteries from WKY. The threshold and EC50 concentrations of NE, 5-HT and KCl were not significantly different between SHR and WKY. Contraction induced by removal of K+ was inhibited by 10(-8) M prazosin. Less than 10(-7) M NE in K(+)-free solution did not cause contraction. Addition of 5.9 mM KCl to K(+)-free solution in the presence of 10(-5) M NE induced relaxation, which was followed by contraction to about the same level as that before KCl addition. The duration of the K(+)-induced relaxation in SHR (22.4 +/- 0.9 min) was slightly, but significantly shorter than that in WKY (26.6 +/- 0.8 min) arteries. In K(+)-free solution with reduced Na+, the duration of the relaxation induced by KCl was shorter than that in the normal solution, for both SHR (13.8 +/- 0.3 min) and WKY (14.1 +/- 0.5 min). Such differences could be caused by increased influx and decreased efflux of Ca2+, which depend on the Na+ concentration and are related to the Na(+)-Ca2+ exchange. The results suggest that enhanced renal vascular reactivity in hypertension may depend on structural changes and increased Na+ pump activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
6
|
pubmed:volume |
200
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-31
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1664326-Animals,
pubmed-meshheading:1664326-Body Weight,
pubmed-meshheading:1664326-Calcium,
pubmed-meshheading:1664326-Hypertension,
pubmed-meshheading:1664326-Kidney,
pubmed-meshheading:1664326-Male,
pubmed-meshheading:1664326-Muscle, Smooth, Vascular,
pubmed-meshheading:1664326-Muscle Contraction,
pubmed-meshheading:1664326-Norepinephrine,
pubmed-meshheading:1664326-Organ Size,
pubmed-meshheading:1664326-Rats,
pubmed-meshheading:1664326-Rats, Inbred SHR,
pubmed-meshheading:1664326-Rats, Inbred WKY,
pubmed-meshheading:1664326-Renal Artery,
pubmed-meshheading:1664326-Serotonin,
pubmed-meshheading:1664326-Sodium-Potassium-Exchanging ATPase
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pubmed:year |
1991
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pubmed:articleTitle |
Sodium pump activity and contraction of renal artery from spontaneously hypertensive rats.
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pubmed:affiliation |
2nd Department of Physiology, Showa University, School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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