Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-4-28
pubmed:abstractText
Serotonin receptor (5-HT(7)) binding assay-directed fractionation of a methanol extract of the dried roots of Angelica sinensis led to the isolation and identification of 21 compounds including a new phenolic ester, angeliferulate (1), and three new phthalides, 10-angeloylbutylphthalide (2), sinaspirolide (3), and ansaspirolide (4), along with 17 known compounds, p-hydroxyphenethyl trans-ferulate (5), Z-ligustilide (6), Z-butylidenephthalide (7), senkyunolide I (8), Z-6-hydroxy-7-methoxydihydroligustilide (9), N-butylbenzenesulfonamide (10), 11(S),16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate (11), (3R,8S)-falcarindiol (12), heptadeca-1-en-9,10-epoxy-4,6-diyne-3,8-diol (13), oplopandiol (14), 8-hydroxy-1-methoxy-, Z-9-heptadecene-4,6-diyn-3-one (15), imperatorin, ferulic acid, vanillin, stigmasterol, sucrose, and 1,3-dilinolenin. This is the first report of a sulfonamide (10) identified from a higher plant source, although its presence needs further investigation. Biosynthetic pathways for dimeric phthalides 3 and 4 are proposed. Compounds 5, 7, 11, 12, 15, and imperatorin exhibited affinity toward 5-HT(7) receptors in a competitive binding assay.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-10805572, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-11368622, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-11596237, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-12525030, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-12648532, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-1318585, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-15139126, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-15584243, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-15789549, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-17268969, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-17402120, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-2054881, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-2156831, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-3671555, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-7582481, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-7908055, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-7984266, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-7988681, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-9326273, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-9392889, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-9418683, http://linkedlifedata.com/resource/pubmed/commentcorrection/16643021-9871635
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0163-3864
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
536-41
pubmed:dateRevised
2010-9-16
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.
pubmed:affiliation
UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural