Linked Life Data

16642968

Source:http://linkedlifedata.com/resource/pubmed/id/16642968

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-4-28
pubmed:abstractText
The purpose of this study was to determine the effect of melanin on skin response to single 3.8-microm, 8-micros laser pulses and the difference in lesion formation thresholds. Our hypothesis was that pigmentation would play a significant role in skin energy absorption at 3.8 microm. Previous studies comparing pigmented and lightly pigmented porcine skin with human skin found that compared with Yorkshire pigs, Yucatan minipigs were a superior model for laser skin exposure because of their higher pigmentation levels. In the current study, 10 pigs under general anesthesia were exposed to 3.8-microm laser pulses ranging from 0.01 J/cm2 to 93 J/cm2. Gross examinations and skin biopsies were done 24 h after laser exposure, and histologic examinations were conducted on these tissue samples. The 24-h effective dose (ED50) was determined to be 4.5 J/cm2 for Yucatan mini-pigs and 2.6 J/cm2 for Yorkshire pigs. As deposited energy was increased, the lesion presentation progressed from desiccation of the superficial layer of epidermis (4 J/cm2) to desiccation with inflammatory centers (14 J/cm2), and finally to replacement of inflammatory areas with an epidermal ulcerated central area (=21 J/cm2). Therefore we found no statistical difference between the 24-h ED50 of the 2 breeds of pigs, nor was there any difference in histologic presentation at 24 h postexposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1559-6109
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-7
pubmed:dateRevised
2006-9-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Response of lightly and highly pigmented porcine skin (Sus scrofa domestica) to single 3.8-microm laser radiation pulses.
pubmed:affiliation
Walter Reed Army Medical Center, Washington, DC, and Colorado State University, Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA.
pubmed:publicationType
Journal Article