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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1992-3-18
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pubmed:abstractText |
This review examines the evidence for the existence in the gastrointestinal tract of a new subtype (H3) of histamine receptors, previously described in the central nervous system. Study of these receptors is facilitated by the availability of the highly selective agonist (R) alpha-methylhistamine and the selective antagonist, thioperamide. H3-receptors seem to exert negative control on gastric acid secretion evoked by indirect cholinergic stimuli: their localization is unclear but it seems to be outside the parietal cell. H3-receptors also seem to be located on cholinergic and non-adrenergic non-cholinergic (NANC) neurones of the myenteric plexus, where they negatively control the release of neurotransmitters.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0269-2813
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
585-91
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1664249-Animals,
pubmed-meshheading:1664249-Digestive System,
pubmed-meshheading:1664249-Digestive System Physiological Phenomena,
pubmed-meshheading:1664249-Gastric Acid,
pubmed-meshheading:1664249-Gastrointestinal Motility,
pubmed-meshheading:1664249-Humans,
pubmed-meshheading:1664249-Neuromuscular Junction,
pubmed-meshheading:1664249-Receptors, Histamine,
pubmed-meshheading:1664249-Receptors, Histamine H3
|
pubmed:year |
1991
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pubmed:articleTitle |
Review article: the histamine H3-receptor: a novel prejunctional receptor regulating gastrointestinal function.
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pubmed:affiliation |
Institute of Pharmacology, University of Parma, Italy.
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pubmed:publicationType |
Journal Article,
Review
|