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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0024623,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0285558,
umls-concept:C0334227,
umls-concept:C0812228,
umls-concept:C1257954,
umls-concept:C1705328,
umls-concept:C1705341
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pubmed:issue |
2-3
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pubmed:dateCreated |
2006-7-31
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pubmed:abstractText |
Inhibition of cyclooxygenase-2 has been proposed to be a potential mechanism for the chemoprevention of gastrointestinal tumors by nonsteroidal anti-inflammatory drugs. This study investigates the mechanisms by which the cyclooxygenase-2 inhibitor SC236 induces apoptosis of gastric cancer cell lines and its downstream signaling pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0012-2823
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pubmed:author |
pubmed-author:ChanAnnie O OAO,
pubmed-author:ChingYick PangYP,
pubmed-author:FanXiao MingXM,
pubmed-author:HeHuaH,
pubmed-author:JiangXiao HuaXH,
pubmed-author:KungHsiang-FuHF,
pubmed-author:LinMarie Chia MiMC,
pubmed-author:RIBIAA,
pubmed-author:WongBenjamin Chun-YuBC,
pubmed-author:XiaHarry H XHH,
pubmed-author:YuenMan FungMF
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pubmed:copyrightInfo |
Copyright 2006 S. Karger AG, Basel.
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-83
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16641552-Acridine Orange,
pubmed-meshheading:16641552-Adenocarcinoma,
pubmed-meshheading:16641552-Apoptosis,
pubmed-meshheading:16641552-Blotting, Western,
pubmed-meshheading:16641552-Caspases,
pubmed-meshheading:16641552-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:16641552-Cytochromes c,
pubmed-meshheading:16641552-Down-Regulation,
pubmed-meshheading:16641552-Enzyme Activation,
pubmed-meshheading:16641552-Humans,
pubmed-meshheading:16641552-Mitogen-Activated Protein Kinases,
pubmed-meshheading:16641552-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:16641552-Pyrazoles,
pubmed-meshheading:16641552-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16641552-Signal Transduction,
pubmed-meshheading:16641552-Stomach Neoplasms,
pubmed-meshheading:16641552-Sulfonamides,
pubmed-meshheading:16641552-Transfection,
pubmed-meshheading:16641552-Tumor Cells, Cultured
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pubmed:year |
2006
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pubmed:articleTitle |
Inhibition of Akt/PKB by a COX-2 inhibitor induces apoptosis in gastric cancer cells.
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pubmed:affiliation |
Department of Medicine, Jinshan Hospital of the Fudan University, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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