Linked Life Data

16641135

Source:http://linkedlifedata.com/resource/pubmed/id/16641135

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-4-27
pubmed:abstractText
The process of apoptosis includes critically important changes on the cell surface that lead to its recognition and removal. The recognition also generates a number of other local tissue responses including suppression of inflammation and immunity. It is surprising that the ligands generated on the apoptotic cell, which mediates these effects, have received relatively little attention. Some of these candidate molecules and possible mechanisms for their surface expression are addressed herein, with particular emphasis on phosphatidylserine and calreticulin. However, exposure of such ligands is exclusive to apoptosis and may, in fact, occur on viable cells. To partially explain the lack of response to such potential stimuli, the presence on viable cells of "don't eat me" signals, in this case, CD47 is suggested to prevent such unwarranted actions. Loss or inactivation of the don't eat me CD47 effects accompanies apoptosis and now allow the cells to be recognized and cleared.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0741-5400
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
896-903
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Recognition ligands on apoptotic cells: a perspective.
pubmed:affiliation
Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural