Linked Life Data

1664028

Source:http://linkedlifedata.com/resource/pubmed/id/1664028

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-3-9
pubmed:abstractText
An information content analysis of protein-binding sites gives a quantitative description of the specificity of the protein, independent of the mechanism of specificity. It gives useful information about the total specificity of the protein and about the individual positions within the binding sites. Information content is consistent with both thermodynamic and statistical analyses of specificity. When applied to a collection of known binding sites, the description provided may be limited by the sample size or by unknown constraints on those sites. Experimental procedures to determine the information content can give much more reliable measures. A large number of functional sites can be obtained from a much larger pool of randomized potential sites. Quantitative assays for the activity of different sites can be easily incorporated into the analysis, thereby increasing its sensitivity. Both in vitro and in vivo experiments are amenable to information content analysis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0076-6879
pubmed:author
pubmed:issnType
Print
pubmed:volume
208
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
458-68
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Probing information content of DNA-binding sites.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.