16639344

Source:http://linkedlifedata.com/resource/pubmed/id/16639344

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0010762, umls-concept:C0013227, umls-concept:C0021853, umls-concept:C0059563, umls-concept:C0205054, umls-concept:C0205263, umls-concept:C0207509, umls-concept:C0441655, umls-concept:C0444706, umls-concept:C0678420, umls-concept:C0939237, umls-concept:C1285572, umls-concept:C1314763, umls-concept:C1332828, umls-concept:C1332829, umls-concept:C1708335
pubmed:issue	1
pubmed:dateCreated	2006-6-9
pubmed:abstractText	The effect of lopinavir/ritonavir (LPV/r) administration on cytochrome P450 (CYP) enzyme activity was quantified using a phenotyping biomarker cocktail. Changes in CYP2C9, CYP2C19, CYP3A, CYP1A2, N-acetyltransferase-2 (NAT-2), and xanthine oxidase (XO) activities were evaluated using warfarin (WARF) + vitamin K, omeprazole (OMP), intravenous (IV) and oral (PO) midazolam (MDZ), and caffeine (CAF).
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/5 U10 HD01313-12, http://linkedlifedata.com/resource/pubmed/grant/AI54980, http://linkedlifedata.com/resource/pubmed/grant/DK56350, http://linkedlifedata.com/resource/pubmed/grant/P30A150410, http://linkedlifedata.com/resource/pubmed/grant/RR00046
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100892005
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/CYP2C19 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CYP2C9 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Caffeine, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A2, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/HIV Protease Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Lopinavir, http://linkedlifedata.com/resource/pubmed/chemical/Midazolam, http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases, http://linkedlifedata.com/resource/pubmed/chemical/Omeprazole, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidinones, http://linkedlifedata.com/resource/pubmed/chemical/Ritonavir, http://linkedlifedata.com/resource/pubmed/chemical/Warfarin
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	1525-4135
pubmed:author	pubmed-author:Baxter-MeheuxFaustinaF, pubmed-author:BlakeMichael JMJ, pubmed-author:EronJoseph JJJJr, pubmed-author:GaverVincent EVE, pubmed-author:KashubaAngela D MAD, pubmed-author:KleinCheri ECE, pubmed-author:PattersonKristine BKB, pubmed-author:RezkNaser LNL, pubmed-author:RubleinJohn CJC, pubmed-author:YehRosa FRF
pubmed:issnType	Print
pubmed:volume	42
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	52-60
pubmed:dateRevised	2011-11-17
pubmed:meshHeading	pubmed-meshheading:16639344-Administration, Oral, pubmed-meshheading:16639344-Adolescent, pubmed-meshheading:16639344-Adult, pubmed-meshheading:16639344-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:16639344-Biological Markers, pubmed-meshheading:16639344-Caffeine, pubmed-meshheading:16639344-Cytochrome P-450 CYP1A2, pubmed-meshheading:16639344-Cytochrome P-450 CYP3A, pubmed-meshheading:16639344-Cytochrome P-450 Enzyme System, pubmed-meshheading:16639344-Drug Therapy, Combination, pubmed-meshheading:16639344-Enzyme Induction, pubmed-meshheading:16639344-Female, pubmed-meshheading:16639344-HIV Protease Inhibitors, pubmed-meshheading:16639344-HIV Seronegativity, pubmed-meshheading:16639344-Humans, pubmed-meshheading:16639344-Injections, Intravenous, pubmed-meshheading:16639344-Intestines, pubmed-meshheading:16639344-Liver, pubmed-meshheading:16639344-Lopinavir, pubmed-meshheading:16639344-Male, pubmed-meshheading:16639344-Midazolam, pubmed-meshheading:16639344-Middle Aged, pubmed-meshheading:16639344-Mixed Function Oxygenases, pubmed-meshheading:16639344-Omeprazole, pubmed-meshheading:16639344-Pyrimidinones, pubmed-meshheading:16639344-Ritonavir, pubmed-meshheading:16639344-Substrate Specificity, pubmed-meshheading:16639344-Warfarin
pubmed:year	2006
pubmed:articleTitle	Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers.
pubmed:affiliation	School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural