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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-4-26
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pubmed:abstractText |
A carboxyl-terminal fragment of tryptophan tRNA synthetase (T2-TrpRS) has demonstrated potent angiostatic activity during retinal developmental neovascularization in vivo. The effects of T2-TrpRS on pathologic neovascularization were tested and compared with a potent VEGF antagonist using the mouse model of oxygen-induced retinopathy (OIR).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiostatic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Aptamers, Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Griffonia simplicifolia lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan-tRNA Ligase,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/monocyte-macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/vascular endothelial growth factor...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2125-34
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16639024-Angiostatic Proteins,
pubmed-meshheading:16639024-Animals,
pubmed-meshheading:16639024-Animals, Newborn,
pubmed-meshheading:16639024-Antigens, CD31,
pubmed-meshheading:16639024-Antigens, Differentiation,
pubmed-meshheading:16639024-Aptamers, Peptide,
pubmed-meshheading:16639024-Disease Models, Animal,
pubmed-meshheading:16639024-Female,
pubmed-meshheading:16639024-Fluorescein Angiography,
pubmed-meshheading:16639024-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:16639024-Hyperoxia,
pubmed-meshheading:16639024-Injections,
pubmed-meshheading:16639024-Male,
pubmed-meshheading:16639024-Mice,
pubmed-meshheading:16639024-Mice, Inbred C57BL,
pubmed-meshheading:16639024-Neovascularization, Physiologic,
pubmed-meshheading:16639024-Oxygen,
pubmed-meshheading:16639024-Plant Lectins,
pubmed-meshheading:16639024-Retinal Neovascularization,
pubmed-meshheading:16639024-Retinal Vessels,
pubmed-meshheading:16639024-Tryptophan-tRNA Ligase,
pubmed-meshheading:16639024-Vascular Endothelial Growth Factor A,
pubmed-meshheading:16639024-Vitreous Body
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pubmed:year |
2006
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pubmed:articleTitle |
T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification.
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pubmed:affiliation |
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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