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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-4-26
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pubmed:abstractText |
Fumagillin and related compounds have potent antiproliferative activity through inhibition of methionine aminopeptidase-2 (MetAP-2). It has recently been reported that MetAP-2 is highly expressed in germinal center B cells and germinal center-derived non-Hodgkin's lymphomas (NHL), suggesting an important role for MetAP-2 in proliferating B cells. Therefore, we determined the importance of MetAP-2 in normal and transformed germinal center B cells by evaluating the effects of MetAP-2 inhibition on the form and function of germinal centers and germinal center-derived NHL cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2583-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16638869-Aminopeptidases,
pubmed-meshheading:16638869-Animals,
pubmed-meshheading:16638869-B-Lymphocytes,
pubmed-meshheading:16638869-Blotting, Western,
pubmed-meshheading:16638869-Cell Line, Tumor,
pubmed-meshheading:16638869-Cell Proliferation,
pubmed-meshheading:16638869-Dose-Response Relationship, Drug,
pubmed-meshheading:16638869-Epoxy Compounds,
pubmed-meshheading:16638869-Female,
pubmed-meshheading:16638869-Germinal Center,
pubmed-meshheading:16638869-Humans,
pubmed-meshheading:16638869-Lymphocyte Count,
pubmed-meshheading:16638869-Lymphoma, B-Cell,
pubmed-meshheading:16638869-Lymphoma, Non-Hodgkin,
pubmed-meshheading:16638869-Macaca fascicularis,
pubmed-meshheading:16638869-Metalloendopeptidases,
pubmed-meshheading:16638869-Mice,
pubmed-meshheading:16638869-Mice, SCID,
pubmed-meshheading:16638869-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:16638869-Time Factors,
pubmed-meshheading:16638869-Valine,
pubmed-meshheading:16638869-Xenograft Model Antitumor Assays
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pubmed:year |
2006
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pubmed:articleTitle |
A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo.
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pubmed:affiliation |
Department of Cell Biology, Repligen, Waltham, Massachusetts, USA.
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pubmed:publicationType |
Journal Article
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