|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2006-4-26
|
|
pubmed:abstractText |
Primary sclerosing cholangitis (PSC) is currently thought to be an immune-mediated disease, where both host genes and environmental factors interact. Some of the immunoregulatory genes responsible for individual susceptibility to PSC have been identified. The co-stimulatory receptor gene cluster on chromosome 2q33 encodes both the positive T-cell regulators CD28 and ICOS, and the negative regulator CTLA4. The CTLA4 gene has been implicated in several immune-mediated diseases, but it is not known whether PSC is associated with any of these genes.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ICOS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0036-5521
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
41
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
586-91
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:16638702-Adolescent,
pubmed-meshheading:16638702-Adult,
pubmed-meshheading:16638702-Aged,
pubmed-meshheading:16638702-Antigens, CD,
pubmed-meshheading:16638702-Antigens, CD28,
pubmed-meshheading:16638702-Antigens, Differentiation,
pubmed-meshheading:16638702-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:16638702-CTLA-4 Antigen,
pubmed-meshheading:16638702-Child,
pubmed-meshheading:16638702-Cholangitis, Sclerosing,
pubmed-meshheading:16638702-Female,
pubmed-meshheading:16638702-Genetic Predisposition to Disease,
pubmed-meshheading:16638702-Humans,
pubmed-meshheading:16638702-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:16638702-Male,
pubmed-meshheading:16638702-Microsatellite Repeats,
pubmed-meshheading:16638702-Middle Aged,
pubmed-meshheading:16638702-Norway
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis.
|
|
pubmed:affiliation |
Medical Department, Rikshospitalet University Hospital, Oslo, Norway. kristine.wiencke@medisin.uio.no
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
