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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-5-29
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pubmed:abstractText |
Xenobiotic metabolizing enzymes (XMEs) are important detoxifiers of hazardous environmental agents, and their polymorphisms may therefore modify the risk of environmentally induced cancers. Consequently, the XME polymorphisms have been extensively studied in this context during recent years. Particular attention has been given to the polymorphisms of glutathione S-transferase (GST) M1, P1 and T1 genes. Previous studies have provided abundant data indicating these polymorphisms as important modifiers of individual susceptibility to cancers of environmental origin. It can be postulated that if the at-risk genotypes of these genes were real risk factors for the environmental cancers, their prevalence would presumably decrease with age in cancer-free part of the population.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0361-090X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
144-51
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pubmed:meshHeading |
pubmed-meshheading:16638627-Adult,
pubmed-meshheading:16638627-Aged,
pubmed-meshheading:16638627-Carcinogens, Environmental,
pubmed-meshheading:16638627-European Continental Ancestry Group,
pubmed-meshheading:16638627-Female,
pubmed-meshheading:16638627-Finland,
pubmed-meshheading:16638627-Genotype,
pubmed-meshheading:16638627-Glutathione S-Transferase pi,
pubmed-meshheading:16638627-Glutathione Transferase,
pubmed-meshheading:16638627-Humans,
pubmed-meshheading:16638627-Male,
pubmed-meshheading:16638627-Middle Aged,
pubmed-meshheading:16638627-Neoplasms,
pubmed-meshheading:16638627-Risk,
pubmed-meshheading:16638627-Smoking
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pubmed:year |
2006
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pubmed:articleTitle |
Distribution of glutathione S-transferase M1, P1 and T1 genotypes in different age-groups of Finns without diagnosed cancer.
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pubmed:affiliation |
Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 41 a A, FI-00250, Helsinki, Finland.
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pubmed:publicationType |
Journal Article
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